| Advance Report | Result | Comment |
|---|---|---|
| NGS Pannel | DBN1/BRAF (Fussion) Positive | Not Detected : ALK,ATRX,EGFR, FGFR1,FGFR2,FGFR3,H3-3A,IDH1, IDH2,MET,MYB,MYBL1, NTRK1,NTRK2,NTRK3, RET,ROS1,TERT,TP53 |
| FISH | 1p/19q co-deletion Negative | |
| MGMT Methylation | Negative | MGMT Promoter methylation |
| Germline NF1 NF2 | Negative | Germline NF1 NF2 (Neurofibromatosis) |
| IHC Marker | Dr Anita-COP Report | Tata Memorial | Neuberg Supratech |
|---|---|---|---|
| Tumor Morphology | Astrocytic morphology, glial tumor | Glial tumor | Low-grade glial neoplasm |
| Cellularity & Pleomorphism | Increased cellularity & nuclear pleomorphism | Not mentioned | Not mentioned |
| Mitosis | Inconspicuous | Not mentioned | Not seen |
| Necrosis | Not seen | Not mentioned | Not seen |
| Microvascular Proliferation | Not seen | Not mentioned | Not seen |
| Olig2 | Positive | Positive | Negative |
| IDH1 R132H | Negative | Negative | Negative |
| ATRX | Retained | Retained | Partially retained nuclear expression |
| H3K27me3 | Retained | Underexpressed | Not tested |
| H3K27M | Not tested | Negative | Negative |
| EZHIP | Not tested | Negative | Not tested |
| P53 | ~15% cells, variable intensity | Few cells positive (wild-type pattern) | Focal weak (wild-type pattern) |
| Ki-67 / MIB-1 | 1–2% | 3–5% in highest proliferating areas | < 1% |
| GFAP, S100, Synaptophysin, SOX10 | Not tested | Not mentioned | All positive |
| Chromogranin, CD34, TTF1 | Not tested | Not tested | All negative |
| MTAP | Not tested | Positive | Not tested |
| p16 | Not tested | Many cells positive | Not tested |